The Red Devils travelled to North London picking up a 1-0 win over Tottenham a couple of weeks ago and have a great chance of doing the same against Arsenal too.
The Gunners come into the game high on confidence after defeating Chelsea 2-0, however, United have been in fantastic form under their new manager.
There could be a start for Alexis Sanchez as the Chilean returns from a long injury lay-off, but there is a doubt with Marcus Rashford struggling for fitness.
This could mean a start for Romelu Lukaku at the Emirates, and here is the predicted line-up for the Red Devils.
Predicted Manchester United XI
Manager: Ole Gunnar Solskjaer
David de Gea (GK)
The Spaniard regained his form after the win over Spurs, and he will be one of the keys in keeping Arsenal from scoring.
Ashley Young (RB)
The former Watford star should continue as our right-back and needs to have a quality game against a battling Arsenal team.
Victor Lindelof (CB)
The Swede has been impressive this season for United. However, this is another tough test for the centre-back as he goes up against Alexandre Lacazette and Pierre-Emerick Aubameyang.
Eric Bailly (CB)
Bailly hasn’t had the greatest of seasons for United, but he could be given a shot in place of Phil Jones on Friday.
Luke Shaw (LB)
Shaw missed the win over Brighton due to illness, and he should be back in the starting XI if he is 100% fit.
Ander Herrera (CM)
The Spaniard should keep his place in the team as it is best not to mess around with a winning formula.
Nemanja Matic (CM)
Matic hasn’t been great under Solskjaer, but the Serbian provides a balance to the midfield.
Paul Pogba (CAM)
Pogba has been the star of the show since Solskjaer took over, and the Frenchman would want to continue his great form under the new manager with a goal against the Gunners.
Jesse Lingard (RW)
Rashford is a doubt and we could see Lingard keep his spot in the team on the right side of the attack.
Romelu Lukaku (ST)
The Belgian needs to have a quality game and going up against a less than stellar Arsenal defence could lead to a few goals for the attacker.
Alexis Sanchez (LW)
There is no better game to play Sanchez than against his former club. The Chilean has missed a huge chunk of the season but should be raring to go against the Gunners.