Manchester United Fixture List for 2022/23 Premier League Season
| Saturday, 27 August 2022 | ||
| Southampton | 12:30 | Manchester United |
| Thursday, 1 September 2022 | ||
| Leicester City | 20:00 | Manchester United |
| Sunday, 4 September 2022 | ||
| Manchester United | 16:30 | Arsenal |
| Sunday, 11 September 2022 | ||
| Crystal Palace | 16:30 | Manchester United |
| Sunday, 18 September 2022 | ||
| Manchester United | 14:00 | Leeds United |
| Sunday, 2 October 2022 | ||
| Manchester City | 14:00 | Manchester United |
| Sunday, 9 October 2022 | ||
| Everton | 19:00 | Manchester United |
| Sunday, 16 October 2022 | ||
| Manchester United | 14:00 | Newcastle United |
| Wednesday, 19 October 2022 | ||
| Manchester United | 20:15 | Tottenham Hotspur |
| Sunday, 23 October 2022 | ||
| Chelsea | 16:30 | Manchester United |
| Sunday, 30 October 2022 | ||
| Manchester United | 16:30 | West Ham United |
| Saturday, 5 November 2022 | ||
| Aston Villa | 15:00 | Manchester United |
| Saturday, 12 November 2022 | ||
| Fulham | 15:00 | Manchester United |
| Monday, 26 December 2022 | ||
| Manchester United | 15:00 | Nottingham Forest |
| Saturday, 31 December 2022 | ||
| Wolverhampton Wanderers | 15:00 | Manchester United |
| Sunday, 2 January 2023 | ||
| Manchester United | 15:00 | Bournemouth |
| Saturday, 14 January 2023 | ||
| Manchester United | 15:00 | Manchester City |
| Saturday, 21 January 2023 | ||
| Arsenal | 15:00 | Manchester United |
| Saturday, 4 February 2023 | ||
| Manchester United | 15:00 | Crystal Palace |
| Saturday, 11 February 2023 | ||
| Leeds United | 15:00 | Manchester United |
| Saturday, 18 February 2023 | ||
| Manchester United | 15:00 | Leicester City |
| Saturday, 25 February 2023 | ||
| Manchester United | 15:00 | Brentford |
| Saturday, 4 March 2023 | ||
| Liverpool | 15:00 | Manchester United |
| Saturday, 11 March 2023 | ||
| Manchester United | 15:00 | Southampton |
| Saturday, 18 March 2023 | ||
| Brighton & Hove Albion | 15:00 | Manchester United |
| Saturday, 1 April 2023 | ||
| Newcastle United | 15:00 | Manchester United |
| Saturday, 8 April 2023 | ||
| Manchester United | 15:00 | Everton |
| Saturday, 15 April 2023 | ||
| Nottingham Forest | 15:00 | Manchester United |
| Saturday, 22 April 2023 | ||
| Manchester United | 15:00 | Chelsea |
| Tuesday, 25 April 2023 | ||
| Tottenham Hotspur | 19:45 | Manchester United |
| Saturday, 29 April 2023 | ||
| Manchester United | 15:00 | Aston Villa |
| Saturday, 6 May 2023 | ||
| West Ham United | 15:00 | Manchester United |
| Saturday, 13 May 2023 | ||
| Manchester United | 15:00 | Wolverhampton Wanderers |
| Saturday, 20 May 2023 | ||
| Bournemouth | 15:00 | Manchester United |
| Saturday, 28 May | ||
| Manchester United | 16:00 | Fulham |
All fixtures are subject to potential change due to European competitions and TV selection.
